Modeling cell clusters and their near-wall dynamics in shear flow

Application of Population Dynamics to Study Heterotypic Cell Aggregations in the Near-Wall Region of a Shear Flow.

Our research focused on the polymorphonuclear neutrophils (PMNs) tethering to the vascular endothelial cells (EC) and the subsequent melanoma cell emboli formation in a shear flow, an important process of tumor cell extravasation from the circulation during metastasis. We applied population balance model based on Smoluchowski coagulation equation to study the heterotypic aggregation between PMN...

Dynamics of vesicles in a wall-bounded shear flow.

We report a detailed study of the behavior (shapes, experienced forces, velocities) of giant lipid vesicles subjected to a shear flow close to a wall. Vesicle buoyancy, size, and reduced volume were separately varied. We show that vesicles are deformed by the flow and exhibit a tank-treading motion with steady orientation. Their shapes are characterized by two nondimensional parameters: the red...

Near-surface shear layer dynamics

The outer surface layers of the sun show a clear deceleration at low latitudes. This is generally thought to be the result of a strong dominance of vertical turbulent motions associated with strong downdrafts. This strong negative radial shear should not only contribute to amplifying the toroidal field locally and to expelling magnetic helicity, but it may also be responsible for producing a st...

Full dynamics of a red blood cell in shear flow.

At the cellular scale, blood fluidity and mass transport depend on the dynamics of red blood cells in blood flow, specifically on their deformation and orientation. These dynamics are governed by cellular rheological properties, such as internal viscosity and cytoskeleton elasticity. In diseases in which cell rheology is altered genetically or by parasitic invasion or by changes in the microenv...

Supporting Information for: The role of near-wall drag effect on the dynamics of tethered DNA under shear flow